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Updated: Sep 15, 2025

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
An observational study of the efficacy of combined orthodontic-systemic periodontal treatment
Shiwei Miao1, Yinghong Wu, Hong Ning
1Department of Stomatology, Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University, Nantong, Jiangsu, China.
Abstract:
This study comparatively analyzes the periodontal status of patients at 6 months after combined orthodontic-systemic periodontal treatment for improving clinical treatment protocols. Eighty periodontitis patients treated in our hospital from June 2019 to June 2022 were selected as subjects and randomly divided into observation and control groups, with 40 patients in each group. The observation group underwent combined orthodontic-systemic periodontal treatment; the control group underwent systemic periodontal treatment. All subjects had been followed up for 6 months, they underwent periodontal clinical examination and gingival crevicular fluid detection at 6 months after treatment; the effective rate was compared between 2 groups. The total effective rate was higher in the observation group (97.50%) than in the control group (87.50%). Compared with before treatment, the clinical attachment loss, gingival bleeding index, periodontal probing depth, plaque index, bleeding on probing, tumor necrosis factor-α, interleukin-6, and interleukin-1β levels in gingival sulcus fluid were significantly decreased in 2 groups at 6 months after treatment, which were lower in the observation group than in the control group, with statistically significant differences (P < .05). Combined orthodontic-systemic periodontal treatment can increase the therapeutic effect, improve periodontal status and enhance anti-inflammatory response in periodontitis patients, thus promoting their recovery.
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