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A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement
Published on: February 22, 2022
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Home-Based High-Intensity Interval Training for People With Parkinson's: A Randomized, Controlled, Feasibility Trial.
Conrad Harpham1, Hilary Gunn1, Jonathan Marsden1
1University of Plymouth Plymouth UK.
Health Science Reports
|July 15, 2025
Summary
Home-based high-intensity interval training (HIIT) is potentially feasible for people with Parkinson's (PwP). However, achieving sufficient intensity and demonstrating benefits requires further investigation before a full trial.
Area of Science:
- Neurology
- Exercise Physiology
- Rehabilitation Science
Background:
- Home-based high-intensity interval training (HIIT) presents a potential avenue for improving the health of people with Parkinson's (PwP).
- No prior home-based HIIT programs have been specifically developed or tested for PwP.
- This study aimed to assess the feasibility, safety, and acceptability of a co-created home-based HIIT program for PwP.
Purpose of the Study:
- To evaluate the feasibility, acceptability, and safety of the HIIT-Home4Parkinson's (HH4P) program.
- To explore potential outcome measures sensitive to change in PwP.
- To gather data to inform the design of a future full-scale clinical trial.
Main Methods:
- A randomized controlled feasibility trial involving 13 independently mobile PwP (Hoehn and Yahr stages 1-3).
- Participants were randomized to either the 12-week HH4P HIIT program (n=7) or usual care (n=6).
- Feasibility and safety were assessed through program completion, adherence, exercise intensity, and adverse events. Potential primary outcomes included serum BDNF, VO2 max, and UPDRS Part III. A qualitative process evaluation was also conducted.
Main Results:
- Six out of seven HIIT participants completed the program; one withdrew due to an unrelated injury.
- Mean adherence was 78.4%, with mean exercise intensity at 77.2% HRmax. Three participants did not consistently achieve 75% HRmax.
- HIIT-related adverse effects were minor and temporary. Most program procedures were deemed feasible and acceptable. No significant benefits were observed in potential primary outcomes compared to the control group.
Conclusions:
- Home-based HIIT appears feasible, safe, and acceptable for some individuals with Parkinson's.
- The ability to consistently achieve target exercise intensity and the potential for clinical benefits remain uncertain.
- Further evaluation of exercise type and support models is needed before recommending progression to a full HH4P trial.
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