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Bromelain Alleviates Sleep Deprivation-Induced Intestinal Injury via TRPA1/5-HT Axis

Hai-Yi Zhang1,2,3, Yan Li1,2,3, Wen-Hao Wang1,2,3

  • 1State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China.

Journal of Agricultural and Food Chemistry
|July 15, 2025
PubMed
Summary

Sleep deprivation causes intestinal damage via hypoxia. Bromelain (BR) mitigates this by reducing 5-HT, a key mediator, offering a new therapeutic target for sleep-related gut issues.

Keywords:
5-HTTRPA1bromelainenterochromaffin cellsintestinal barriersleep deprivation

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