Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

<i>Critical Alliance</i> of AI in Education: A Pedagogical Framework for Safeguarding Cognitive Skills.

International medical education (Basel, Switzerland)·2026

Same author

Impact of Fostamatinib on Inflammatory Biomarkers in Hospitalized Patients With COVID-19.

Critical care explorations·2026

Same author

Synthesis of <sup>15</sup>N-Labeled Bevirimat Derivatives as Isotopic Chemical Probes of HIV-1 Maturation Inhibition.

Magnetic resonance in chemistry : MRC·2026

Same author

Multi-Omics Analysis Defines Endotypes and Systemic Inflammation in Primary Ciliary Dyskinesia: A Comparison with Healthy Controls.

Annals of the American Thoracic Society·2026

Same author

Ventilation-perfusion Scan: A Functional Imaging Approach to Regional Lung Disease in Primary Ciliary Dyskinesia.

The open respiratory medicine journal·2026

Same author

Cilia Dynamics in Primary Ciliary Dyskinesia: A Biophysical Characterization of the <i>RSPH4A</i> Founder Variant.

Cells·2026

Search research articles

Related Experiment Video

Updated: Jun 24, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Evaluating Naphthalene-Modified Metallosalen Complexes as Anticancer Agents.

Jemily Acosta-Mercado^1,2, Angelica Oliveras-Alsina^1,2, Ariana I Marcano-Maiz^1,2

¹Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, 17 Ave Universidad STE 1701, San Juan, Puerto Rico 00925-2537, United States.

Journal of Medicinal Chemistry

|July 15, 2025

Summary

This summary is machine-generated.

Novel platinum (Pt) and palladium (Pd) metallosalens with naphthalene modifications show potent cancer cell killing abilities. These compounds offer a promising, selective approach to cancer therapy with reduced toxicity to healthy cells.

More Related Videos

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

Related Experiment Videos

Last Updated: Jun 24, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

Area of Science:

Medicinal Chemistry
Materials Science
Cancer Biology

Background:

Current cancer therapies face limitations including off-target toxicity and resistance.
Metallosalens, a class of metal-organic compounds, offer unique electronic and structural properties for therapeutic applications.
Naphthalene modification can enhance the biological activity and DNA-binding capabilities of metallosalens.

Purpose of the Study:

To synthesize and characterize novel naphthalene-modified Pt(II) and Pd(II) metallosalens.
To evaluate the DNA-binding affinity and cytotoxic efficacy of these compounds against cancer cell lines.
To assess the selectivity of these metallosalens towards cancer cells versus healthy cells.

Main Methods:

Synthesis and characterization of metallosalens using single crystal X-ray diffraction (sc-XRD), UV-vis spectroscopy, NMR spectroscopy, and elemental analysis.
In vitro biological assays to determine cytotoxicity against A375 (melanoma) and H292 (nonsmall cell lung cancer) cell lines.
Assessment of toxicity in human umbilical artery endothelial cells (HSAEC) and apoptosis induction using Incucyte Caspase-3/7 Green Dye assays.

Main Results:

Naphthalene-modified Pt(II) and Pd(II) metallosalens were successfully synthesized and characterized.
The compounds exhibited strong DNA-binding affinity and enhanced cytotoxic efficacy against tested cancer cell lines.
PtL1 and PtL2 demonstrated significant cancer cell cytotoxicity with minimal toxicity to healthy HSAEC cells, inducing apoptosis selectively.

Conclusions:

Naphthalene-modified metallosalens represent a promising class of compounds for broad-spectrum cancer therapy.
Ligand design and metal coordination are crucial for developing effective chemotherapeutics with improved selectivity.
These metallosalens offer a potential strategy to balance therapeutic efficacy with reduced off-target effects in cancer treatment.