Related Experiment Video
Updated: Sep 15, 2025
07:03
A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
Published on: June 16, 2022
6.5K
Macro and microdistribution of boric acid in compact bone
María Silvina Olivera1, Carlos Ignacio Sallucci2, Marina Carpano1
1Comisión Nacional de Energía Atómica (CNEA), Centros Atómicos Constituyentes y Ezeiza, Buenos Aires, Argentina.
Summary
Boric acid (BA) shows high boron accumulation in rat bone, unlike boronophenylalanine (BPA). This study investigated BA
Area of Science:
- Nuclear medicine
- Radiochemistry
- Biomedical engineering
Background:
- Boronophenylalanine (BPA) biodistribution for Boron Neutron Capture Therapy (BNCT) is known.
- Limited data exists on boric acid (BA) biodistribution, especially concerning bone accumulation.
Purpose of the Study:
- To comparatively evaluate the accumulation and retention of boric acid (BA) in bone tissue.
- To investigate boron microdistribution in compact bone using optimized neutron autoradiography.
Main Methods:
- Wistar rats received infusions of BA (40 and 200 ppm boron) or BPA (40 ppm boron).
- Boron concentrations were quantified in bone and organs using ICP-OES.
- Neutron autoradiography was employed to visualize boron microdistribution in bone samples.
Main Results:
- Both ICP-OES and neutron autoradiography showed high boron concentrations in bone.
- Findings suggest preferential boron accumulation in the bone's mineral matrix.
- A novel sample preparation method was developed for accurate boron microdistribution analysis.
Conclusions:
- Boric acid (BA) demonstrates significant accumulation in bone tissue.
- BA's bone-targeting properties may be relevant for BNCT applications and radiotoxicity assessments.
Keywords:
Boric acidBoron Neutron Capture TherapyBoronophenylalanineCompact boneICP-OESNeutron autoradiographyMore Related Videos
Related Concept Videos
01:27Compact Bone
12.8K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
12.8K
01:18The Bone Matrix
4.5K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
4.5K
01:31Essential Minerals for Bone Health
4.4K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.4K
01:09Spongy Bone
5.4K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
5.4K
01:23Bone as Supporting Connective Tissue
4.2K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
4.2K
01:55Bone Structure
49.1K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
49.1K