High-Sensitivity Troponin Zones: An Alternative Approach to Clinical Decisions

High-Sensitivity Troponin test results span a wide range of clinical values, from <5 ng/L to >5000 ng/L.

At the low end of the spectrum (≤100 ng/L for most assays), there are several domains with unique decision points based upon thresholds derived from validation studies. Thus, we propose a novel Trop-Zone approach as an evidence-based and user-friendly guide to clinical decision-making within these domains.

In this review, we aim to provide a concise summary of recent Guidelines, describe the impact of validation studies, and propose a novel "Trop-Zone" approach that we believe is simpler than existing flowcharts.