Related Experiment Video
Updated: Sep 15, 2025

12:58
Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy
Published on: September 12, 2019
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Bifunctional nanodisc platforms for studies on self-assembly and amyloid fibrillation
Bikash R Sahoo1, Takahiro Watanabe-Nakayama2, Saba Suladze3
1Biophysics, Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. bsahoo@umich.edu.
Abstract
None:
Nanodiscs are emerging as valuable tools for studying lipid-protein interactions. In this study, we demonstrate the dual role of nanodiscs in modulating human amylin (hIAPP) fibrillation using NMR and HS-AFM. Peptide-based nanodiscs promote hIAPP fibrillation, while polymer-based nanodiscs inhibit aggregation. These findings broaden the applications of nanodiscs beyond structural studies.

