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Updated: May 5, 2026

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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Intracorneal Ring Segments in Keratoconus: A Narrative Literature Review
Usman K Hayat1, Haaris A Shiwani1, Danyal Memon2
1Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester, UK.
Clinical Ophthalmology (Auckland, N.Z.)
|July 16, 2025
Summary
Intracorneal ring segments (ICRS) offer an effective vision enhancement for keratoconus patients, reducing the need for corneal transplants. This review details ICRS types, techniques, and outcomes for managing this corneal ectasia.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Vision Rehabilitation
Background:
- Keratoconus is a progressive corneal ectasia causing irregular astigmatism and high myopia.
- Treatment options include corneal collagen cross-linking (CXL), contact lenses, intracorneal ring segments (ICRS), phakic intraocular lenses, and corneal transplantation.
- Intracorneal ring segments (ICRS) are implants designed to reshape the cornea and improve refractive outcomes.
Purpose of the Study:
- To review the different types of intracorneal ring segments (ICRS) used for keratoconus.
- To explore surgical techniques and emerging developments in ICRS implantation.
- To evaluate the efficacy and safety of ICRS in managing keratoconus.
Main Methods:
- A literature review was conducted using PubMed.
- 117 peer-reviewed manuscripts were analyzed, including reviews, RCTs, case series, and reports.
- Reference lists of publications were also reviewed.
Main Results:
- Various ICRS types exist, including MyoRings, KeraRings, Ferrara Rings, and Intacs.
- Femtosecond laser-assisted tunnel creation improves precision and reduces complications.
- ICRS implantation leads to corneal flattening, astigmatism reduction, and slight corneal stiffening with low complication rates.
Conclusions:
- ICRS are an effective vision enhancement option for select keratoconus patients, potentially avoiding corneal transplants.
- ICRS are particularly useful for contact lens-intolerant patients without central corneal scarring.
- Future research should focus on long-term outcomes and combination therapies like ICRS with CXL.

