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11α-hydroxydysobinin: a new limonoid from Chisocheton macrophyllus seeds (Meliaceae)
1, Lulu Wilden Azzahra1, Wahyu Safriansyah1
1Natural Products Chemistry and Synthesis Laboratory, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Abstract:
A new limonoid compound 11α-hydroxydisobinin (1), along with a known limonoid compound (2), was isolated from ethyl acetate extract of Chisocheton macrophyllus (Meliaceae) seeds. The structure and stereochemical configuration of compound 1 was characterized by HR-ESI-MS, UV, IR, NMR, and ECD analysis through quantum chemical calculations (TD-DFT analysis and DP4+ NMR). Both limonoids were tested for their cytotoxic activities against MCF-7 breast cancer cells with IC50 values of 112.5 and 51.7 µM.
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