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Published on: June 20, 2014
Asymmetric synthesis and biological evaluation of ottensinin and its analogues
Jun-Ting Liang1, Zichen Xu1, Yong-Bin Xie1
1State Key Laboratory of Bioactive Molecules and Druggability Assessment, Institute for Advanced and Applied Chemical Synthesis, College of Pharmacy, Jinan University, Guangzhou 510632, China. heyutao7@jnu.edu.cn.
Abstract:
The asymmetric synthesis of ottensinin, a rearranged labdane diterpene with a broad range of favourable bioactivities, has been realized based on fragment coupling of 16a and 13 in eight steps from (+)-sclareolide. This approach would enable the diverse synthesis of ottensinin analogues to facilitate future drug development based on ottensinin.
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