Detection of phenolalkylamines by capillary column gas chromatography-negative chemical ionization mass spectrometry

Twelve phenolalkylamines normally used in different pharmaceutical products were determined in urine from volunteers given a therapeutical dose of the drug. The urine extracts were first derivatized with perfluoro propionic or butyric anhydride, then detected by capillary gas chromatography-negative chemical ionization mass spectrometry. The method is highly sensitive and specific in the analysis of biological samples.