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Related Concept Videos

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
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Related Experiment Video

Updated: Sep 15, 2025

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
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Dynamic Evaluation of Colitis-Associated Colorectal Cancer Using Multimodal US-OCT-NIRF System.

Ruiming Kong, Cuixia Dai, Bing Wang

    IEEE Transactions on Bio-Medical Engineering
    |July 16, 2025
    PubMed
    Summary
    This summary is machine-generated.

    A new multimodal imaging system combining optical coherence tomography (OCT), ultrasonography (US), and near-infrared fluorescence (NIRF) shows promise for early detection of colitis-associated colorectal cancer (CAC). This technology visualizes both vascular and structural changes, aiding in distinguishing malignancy from inflammation.

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    Area of Science:

    • Gastroenterology
    • Biomedical Engineering
    • Oncology

    Background:

    • Colitis-associated colorectal cancer (CAC) presents diagnostic challenges, often difficult to differentiate from inflammation using current imaging.
    • Early detection of CAC is crucial for improving patient prognosis and treatment outcomes.

    Purpose of the Study:

    • To evaluate a novel multimodal endoscopic imaging system integrating OCT, US, and NIRF for enhanced CAC detection.
    • To assess the system's capability in visualizing both vascular and morphological changes associated with CAC progression.

    Main Methods:

    • Integration of OCT, US, and NIRF imaging with BSA-ICG nanocomplexes for enhanced visualization.
    • Utilizing NIRF for capillary network visualization and OCT/US for morphological assessment.
    • Application in a CAC mouse model to monitor disease progression from inflammation to tumor formation.

    Main Results:

    • The system successfully identified early morphological and vascular alterations in CAC, including capillary network changes and tissue thickening.
    • High-resolution fluorescence imaging visualized colonic capillaries, while OCT and US provided insights into inflammation-to-malignancy progression.
    • Demonstrated ability to monitor dynamic changes during CAC development in vivo.

    Conclusions:

    • The multimodal imaging system holds significant potential for early and accurate in vivo detection of CAC.
    • Simultaneous visualization of vascular and morphological changes aids in understanding carcinogenesis and disease progression.
    • This technique may improve diagnostic accuracy, guide therapeutic interventions, and enhance patient management for CAC.