Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ethics in Research01:56

Ethics in Research

24.0K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
24.0K
Psychosurgery01:30

Psychosurgery

114
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
114
Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

287
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
287
Altered States of Awareness01:06

Altered States of Awareness

483
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
483
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

252
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
252
Clinical Trials01:16

Clinical Trials

8.6K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic review of approaches to informed consent in recent high-impact clinical trials.

Journal of clinical and translational science·2026
Same author

Are Psychedelics Ethically Exceptional After All? Some Further Reflections.

The American journal of bioethics : AJOB·2026
Same author

Analyzing the concept of independence in psychedelic research.

Accountability in research·2026
Same author

Causal Inference in Studies with Functional Unmasking: Psychedelics and Beyond.

medRxiv : the preprint server for health sciences·2025
Same author

Overdue: Delayed Revision of Institutional Review Board Policies Characterizing Pregnant Women After the Revised Common Rule.

Annals of internal medicine·2025
Same author

Social Value Communication Amidst the "Hype" of Psychedelic Research.

The American journal of bioethics : AJOB·2025
Same journal

"I Have Someone's Life in my Hands": How Cancer Care Partners Experience and Navigate Moral Challenges.

AJOB empirical bioethics·2026
Same journal

"It's an Uphill Battle. We Have a Long Way to Go": Perspectives of Canadian Individuals Living with Genetic Conditions Detectable by Prenatal Cell-Free DNA Screening.

AJOB empirical bioethics·2026
Same journal

Psychological Harms of HIV Vaccine Trial Participation in Tanzania: Could Post-Trial Participants Engagement Help?

AJOB empirical bioethics·2026
Same journal

Canadian Medical Assistance in Dying (MAID) and Access to Resources: An Analysis of Media Reports.

AJOB empirical bioethics·2026
Same journal

Do Reasons Matter? An Empirical Exploration of the Role of Parents' Reasons in Treatment Refusal in Pediatric Oncology.

AJOB empirical bioethics·2026
Same journal

Ethical Dilemmas at Student-Run Clinics: A Narrative Review.

AJOB empirical bioethics·2026
See all related articles

Related Experiment Video

Updated: Sep 15, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.0K

Informed Consent Documents from Psychedelic Clinical Trials: A Descriptive Ethical Analysis.

Katherine Cheung1, Caleigh Propes1, Marianna Graziosi2,3

  • 1Berman Institute of Bioethics & Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.

AJOB Empirical Bioethics
|July 16, 2025
PubMed
Summary
This summary is machine-generated.

Informed consent documents (ICDs) in psychedelic trials often emphasize mental and physical risks. However, they less frequently include psychedelic-specific experiences like ineffability, which bioethicists suggest are crucial for participant understanding.

Keywords:
Psychedelicclinical trialsenhanced consentinformed consentpsilocybinpsychedelic bioethics

More Related Videos

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness
04:04

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

Published on: July 11, 2025

302
A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
08:42

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

Published on: July 31, 2017

8.3K

Related Experiment Videos

Last Updated: Sep 15, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.0K
Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness
04:04

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

Published on: July 11, 2025

302
A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
08:42

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

Published on: July 31, 2017

8.3K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Bioethics

Background:

  • Classic psychedelics like psilocybin and LSD induce altered states of consciousness.
  • The unique nature of psychedelic experiences, such as ineffability, presents challenges for informed consent.
  • There is a growing debate on tailoring informed consent documents (ICDs) for psychedelic research.

Purpose of the Study:

  • To analyze and describe the content of ICDs used in contemporary psilocybin clinical trials.
  • To compare the content of these ICDs with recommendations from psychedelic bioethics literature.

Main Methods:

  • A content analysis approach was used to review 28 ICDs from 28 psilocybin clinical trials across 13 US sites.
  • Coders demonstrated good inter-rater reliability (κ = .683).

Main Results:

  • ICDs predominantly focused on general risks, such as mental health and physical risks, aligning with bioethical expectations.
  • Psychedelic-specific elements, including ineffability and therapeutic touch, were notably underrepresented in the analyzed ICDs.

Conclusions:

  • While ICDs cover common risks, they often omit crucial psychedelic-specific aspects highlighted in bioethical discussions.
  • Further debate is needed to determine the most salient information for ICDs to ensure truly informed consent in psychedelic research.
  • The study provides a table of best practices observed in the analyzed ICDs.