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Dextran-based vehicle for gene transfection: A lesson learned by nature
Sara Masoumi Shahrbabak1, Vahid Tayebi-Khorrami2, Mohammad Reza Fadaei2
1Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Science, Tehran, Iran.
International Journal of Biological Macromolecules
|July 16, 2025
Summary
Dextran-based gene delivery systems offer a versatile and cost-effective alternative to viral vectors. Chemical modifications enhance their performance for various therapeutic applications, including gene editing.
Area of Science:
- Biomaterials Science
- Gene Therapy
- Nanotechnology
Background:
- Dextran offers biocompatibility, solubility, and cost-effectiveness as a non-viral gene delivery vector.
- Its ease of chemical modification allows for tailored properties in gene delivery systems.
Purpose of the Study:
- To review the advantages and applications of dextran-based vehicles for nucleic acid transfection.
- To highlight the impact of dextran modifications on gene delivery efficiency and targeting.
Main Methods:
- Review of existing literature on dextran-based gene delivery systems.
- Analysis of chemical modifications (acetylation, oxidation, carboxymethylation) and their effects.
- Examination of diverse dextran-based system designs (micro, nano, conjugated, hybrid).
Main Results:
- Dextran modifications improve gene material stability, circulation time, and transfection efficiency.
- Functionalization enables targeted delivery and stimuli-responsive release.
- Dextran-based systems show promise in disease treatment and gene editing applications.
Conclusions:
- Dextran-based gene delivery systems present a versatile, efficient, and tunable platform.
- Further research into challenges and limitations will optimize their clinical translation.
