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Related Concept Videos

Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Related Experiment Video

Updated: Sep 15, 2025

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
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Amyloidosis and the Liver.

Rama Tarakji1, Paul Martin2, Gabriel Perreault2

  • 1Department of Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA.

Clinics in Liver Disease
|July 16, 2025
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Amyloidosis involves misfolded protein deposition, often affecting the liver. This review covers hepatic amyloidosis, its management, and emerging targeted therapies for better patient outcomes.

Keywords:
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Area of Science:

  • Hepatology
  • Gastroenterology
  • Internal Medicine

Background:

  • Amyloidosis is a complex disease characterized by misfolded protein deposition.
  • The liver is frequently involved in amyloidosis, serving as both a target and source of abnormal proteins.
  • Gastroenterologists and hepatologists are crucial in managing patients with hepatic amyloidosis.

Purpose of the Study:

  • To review common forms of amyloidosis.
  • To emphasize hepatic manifestations and complications of amyloidosis.
  • To discuss liver-directed therapies, including transplantation and novel treatments.

Main Methods:

  • Literature review of amyloidosis.
  • Focus on hepatic involvement in amyloidosis.
  • Analysis of current and emerging therapeutic strategies.

Main Results:

  • Amyloidosis presents diverse hepatic manifestations.
  • Effective management of hepatic complications is vital.
  • Liver transplantation and targeted therapies offer treatment options.

Conclusions:

  • Hepatic involvement is a significant aspect of amyloidosis.
  • Multidisciplinary care is essential for managing amyloidosis.
  • Advancements in targeted therapies are improving treatment for hepatic amyloidosis.