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Hepatotoxicity of Chemotherapy and Immune Checkpoint Inhibitors
Peter D Block1, David N Assis2
1Division of Gastroenterology and Hepatology, New York University Grossman School of Medicine, NYU Langone Gastroenterology and Hepatology Associates, 150 East 32nd Street, Suite 101, New York, NY 10016, USA.
Clinics in Liver Disease
|July 16, 2025
Summary
Oncologic drug-induced liver injury presents complex challenges. A systematic, multidisciplinary approach involving oncology and hepatology is crucial for managing drug hepatotoxicity and preserving liver function.
Area of Science:
- Oncology
- Hepatology
- Clinical Pharmacology
Background:
- Hepatotoxicity from cancer therapies poses a significant clinical challenge.
- Managing drug-induced liver injury requires balancing cancer treatment with liver function preservation.
- Complex patient presentations and multi-drug regimens complicate diagnosis and treatment.
Purpose of the Study:
- To provide a contemporary review of drug-induced liver injury in oncology.
- To discuss the pathophysiology and presentation patterns of key hepatotoxic agents.
- To outline diagnostic strategies and management principles for oncologic drug hepatotoxicity.
Main Methods:
- Literature review of oncologic drug hepatotoxicity.
- Analysis of drug classes and specific agents causing liver injury.
- Discussion of diagnostic approaches and management strategies.
Main Results:
- Hepatotoxicity is a growing concern in cancer care.
- Specific drug classes exhibit distinct patterns of liver injury.
- Sinusoidal obstruction syndrome is a notable presentation of drug-induced liver injury.
Conclusions:
- A systematic, multidisciplinary approach is essential for managing drug-induced liver injury in cancer patients.
- Effective management requires collaboration between oncology and hepatology specialists.
- Understanding pathophysiology and diagnostic patterns aids in optimizing patient care.
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