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Updated: Sep 15, 2025

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Hepatotoxicity of Chemotherapy and Immune Checkpoint Inhibitors
Peter D Block1, David N Assis2
1Division of Gastroenterology and Hepatology, New York University Grossman School of Medicine, NYU Langone Gastroenterology and Hepatology Associates, 150 East 32nd Street, Suite 101, New York, NY 10016, USA.
Abstract:
Hepatotoxicity from oncologic drugs represents an increasing clinical burden for patients, providers, and the health care system. The complexity of clinical presentations, multi-drug regimens, and the need to control the underlying cancer while preserving liver function, results in significant diagnostic and therapeutic challenges. These challenges are best met with a careful and systematic approach with multi-disciplinary management decisions between oncology and hepatology providers. This contemporary review discusses the known pathophysiology and patterns of hepatotoxicity for key drug classes and agents, including unique presentations such as sinusoidal obstruction syndrome, key aspects of the diagnostic approach, and principles of management.
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