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Related Experiment Video

Updated: Sep 15, 2025

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models
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Injury-specific pathways shape corneal nerve regeneration dynamics.

Léna Meneux1, Sarah Pernot1, Nadège Feret1

  • 1Institute for Neurosciences of Montpellier, INSERM, Univ Montpellier, Montpellier, France.

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|July 16, 2025
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Summary
This summary is machine-generated.

Corneal nerve regeneration varies significantly after injury. Understanding these differences in nerve repair is crucial for developing effective treatments for neurotrophic keratitis (NK) and other neuropathies.

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CorneaDevelopmentInnervationRegeneration

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Regenerative Medicine

Background:

  • Corneal nerves are vital for vision and ocular surface health.
  • Damage to corneal nerves causes neurotrophic keratitis (NK), impairing healing and vision.
  • Regenerative mechanisms in NK and other peripheral neuropathies are poorly understood.

Purpose of the Study:

  • To investigate corneal nerve regeneration after axotomy and epithelial abrasion.
  • To compare structural and functional recovery based on injury type.
  • To identify injury-specific molecular pathways influencing nerve repair.

Main Methods:

  • Induction of axotomy and epithelial abrasion models in corneal tissue.
  • Assessment of nerve regeneration, epithelial cell homeostasis, and corneal damage.
  • Analysis of molecular pathways activated by different injury types.

Main Results:

  • Axotomy led to delayed nerve regeneration, disrupted epithelial homeostasis, and increased corneal damage.
  • Epithelial abrasion resulted in rapid but structurally abnormal nerve recovery.
  • Distinct molecular pathways were activated depending on the injury type.

Conclusions:

  • Corneal nerve regeneration is highly dependent on the type of injury.
  • Targeted therapeutic strategies are needed for NK and peripheral neuropathies.
  • This study provides insights into nerve repair variability for novel treatment development.