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Motor and Sensory Areas of the Cortex01:14

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The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
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Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
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The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
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Signal sequences are short amino acid sequences that guide newly synthesized proteins to their proper location within the cell. Classical signal sequences are fifteen to sixty amino acids long and present at the N-terminus of a polypeptide chain. Each signal sequence has a conserved segment of basic residues towards their N terminus, a hydrophobic core, and a C-terminus rich in polar residues. The C-terminus also contains a signal cleavage site and features a -3 -1 sequence motif. The -3-1...
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Auditory Pathway01:15

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Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
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Related Experiment Video

Updated: Sep 15, 2025

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

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Speech sequencing in the human precentral gyrus.

Jessie R Liu1,2,3, Lingyun Zhao1,2, Patrick W Hullett1,2,4

  • 1Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.

Nature Human Behaviour
|July 16, 2025
PubMed
Summary

This study reveals that sustained neural activity in the middle precentral gyrus (mPrCG) is crucial for speech-motor sequencing. Disrupting this area causes speech disfluencies, highlighting its central role in planning and producing complex speech sounds.

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Area of Science:

  • Neuroscience
  • Speech Science
  • Motor Control

Background:

  • Fluent speech relies on precise motor planning and sequencing of speech sounds.
  • The neural mechanisms underlying speech-motor sequencing are not fully understood.
  • Identifying the specific brain regions involved is key to understanding speech production.

Purpose of the Study:

  • To investigate the neural basis of speech-motor sequencing.
  • To identify brain regions involved in preparing and executing sequential speech motor plans.
  • To explore the role of the middle precentral gyrus (mPrCG) in speech sequencing.

Main Methods:

  • High-density direct cortical recordings were performed in 14 participants during speech tasks.
  • Participants produced utterances with varying phonemic and syllabic sequence complexity.
  • Electrocortical stimulation of the middle precentral gyrus (mPrCG) was used to assess its function.

Main Results:

  • Sustained neural activity was observed throughout speech production, delay, and target presentation phases.
  • Activity in the middle precentral gyrus (mPrCG) correlated with sequence complexity and reaction time.
  • Electrocortical stimulation of the mPrCG induced speech disfluencies similar to apraxia of speech.

Conclusions:

  • Speech-motor sequencing involves a distributed cortical network.
  • The middle precentral gyrus (mPrCG) plays a critical role in speech-motor sequencing.
  • The mPrCG is essential for preparing and executing complex speech sound sequences.