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Stereotactic Radiosurgery for Gynecologic Cancer
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Moderately hypofractionated online adaptive radiotherapy (SWIFT-1) in cervical cancer patients: study protocol for a
Zheng Zeng1, Yining Chen2, Jie Qiu1
1Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, NO.1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing, 100730, China.
Radiation Oncology (London, England)
|July 16, 2025
Summary
This trial compares moderately hypofractionated radiotherapy (MHRT) with conventional fractionated radiotherapy (CFRT) for locally advanced cervical cancer. It will determine if MHRT is a safe and effective alternative to CFRT, potentially reducing treatment burden.
Area of Science:
- Oncology
- Radiation Oncology
- Clinical Trials
Background:
- External beam radiotherapy (EBRT) is standard for locally advanced cervical cancer.
- Moderately hypofractionated radiotherapy (MHRT) may reduce treatment burden but requires more evidence.
- Existing studies may overestimate MHRT toxicity due to lack of modern techniques.
Purpose of the Study:
- To evaluate the non-inferiority of moderately hypofractionated online adaptive radiotherapy (oART) versus conventional fractionated radiotherapy (CFRT).
- To assess the efficacy and safety of MHRT as an alternative to CFRT in cervical cancer treatment.
- To investigate the potential of oART in locally advanced cervical cancer management.
Main Methods:
- Prospective, multi-center, randomized controlled, non-inferiority phase III trial.
- 440 participants randomized 1:1 to MHRT or CFRT, both with concurrent chemoradiotherapy.
- Primary endpoint: 3-year progression-free survival; secondary endpoints include toxicity and quality of life.
Main Results:
- This section will be populated upon study completion.
Conclusions:
- This trial will prospectively assess MHRT non-inferiority to CFRT in efficacy and safety.
- It will evaluate moderately hypofractionated oART as a viable alternative for locally advanced cervical cancer.
- Results will inform clinical practice regarding hypofractionated radiotherapy in cervical cancer.
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