Regional Infantile Hemangiomas Associated With Raynaud Phenomenon

Racquel A Bitar1,2, Sarah E Servattalab2, Lauren A Henderson3

  • 1Vascular Anomalies Center, Boston Children's Hospital, Boston, Massachusetts, USA.

Pediatric Dermatology
|July 17, 2025
PubMed

Regional (segmental) infantile hemangioma (IH) can be associated with arterial anomalies, as seen in PHACE (posterior fossa anomalies, hemangioma, arterial anomalies, cardiac anomalies, and eye anomalies) and LUMBAR (lower body infantile hemangiomas, urogenital anomalies and ulceration, myelopathy, bony deformities, anorectal malformations and arterial anomalies, and rectal anomalies) associations. We describe two patients with a regional IH on the hand associated with Raynaud phenomenon. We hypothesize that Raynaud phenomenon in the setting of a regional IH may be due to post-traumatic vasospastic response, arterial anomalies, cutaneous atrophy due to the IH, and/or changes in vasomotor regulation.

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