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Regional Infantile Hemangiomas Associated With Raynaud Phenomenon
Racquel A Bitar1,2, Sarah E Servattalab2, Lauren A Henderson3
1Vascular Anomalies Center, Boston Children's Hospital, Boston, Massachusetts, USA.
Pediatric Dermatology
|July 17, 2025
Summary
Regional infantile hemangiomas (IH) on the hand may be linked to Raynaud phenomenon. This association could stem from various vascular and tissue-related factors, warranting further investigation.
Area of Science:
- Vascular anomalies
- Dermatology
- Pediatric medicine
Background:
- Regional infantile hemangiomas (IH) are associated with syndromes like PHACE and LUMBAR, involving arterial anomalies.
- These syndromes highlight the link between vascular malformations and systemic complications.
Observation:
- Two cases of regional infantile hemangioma on the hand are presented.
- Both patients exhibited associated Raynaud phenomenon.
Findings:
- The study explores potential causes for Raynaud phenomenon in patients with regional IH.
- Hypothesized causes include post-traumatic vasospasm, underlying arterial anomalies, IH-induced cutaneous atrophy, and altered vasomotor regulation.
Implications:
- Recognizing this association may improve diagnosis and management of hand IH.
- Further research is needed to elucidate the pathophysiology of Raynaud phenomenon in this context.
- This finding could inform clinical evaluation for patients with regional IH.
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