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Socioeconomic Differences in Global Brain Asymmetry: An Integrative Approach Using Image Similarity Measures and
María Eugenia Bernaschini1,2, Grisel Maribel Britos1,2, Adrián Maximiliano Moneta Pizarro3
1Centro de Investigación y Estudios de Matemática, Consejo Nacional de Investigaciones Científicas y Técnicas, Haya de la Torre y Medina Allende S/N, Ciudad Universitaria, X5000HRV, Córdoba, Argentina.
Research Square
|July 17, 2025
Summary
Socioeconomic status (SES) significantly impacts brain asymmetry, with higher SES linked to more pronounced asymmetry. Brain asymmetry also increases with age and is greater in males than females.
Area of Science:
- Neuroscience
- Human Brain Development
- Cognitive Science
Background:
- Human brain exhibits bilateral asymmetry, observable in MRI grayscale levels.
- Brain asymmetry is crucial for higher-level cognition.
- Socioeconomic and biological factors influence brain asymmetry.
Purpose of the Study:
- Investigate the relationship between brain asymmetry and socioeconomic status (SES).
- Examine the influence of age and sex on brain asymmetry.
Main Methods:
- Developed a novel global index of brain asymmetry.
- Combined Gradient Magnitude Similarity Deviation for 2D slice asymmetry assessment.
- Utilized Multiple Indicators Multiple Causes (MIMIC) Structural Equation Modeling to create a global index.
Main Results:
- Significant association found between SES and brain asymmetry.
- Higher SES individuals showed more pronounced brain asymmetry.
- Brain asymmetry increased with age and was higher in males than females.
Conclusions:
- Socioeconomic factors, particularly SES, are relevant to structural brain characteristics.
- Findings provide new insights into the link between socioeconomic factors and brain asymmetry.
