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Poncet's Disease: A Case-Based Review.

Soukaina Zaher1, Kawtar Nassar1, Saadia Janani1

  • 1Department of Rheumatology, Ibn Rochd University Hospital Center, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, MAR.

Cureus
|July 17, 2025
PubMed
Summary
This summary is machine-generated.

Poncet's disease, a rare form of reactive arthritis linked to tuberculosis (TB), can present as inflammatory joint pain. Early diagnosis and anti-TB treatment are crucial for managing this condition.

Keywords:
antitubercular drugspolyarthralgiaponcet’s diseasereactive arthritistuberculosis

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Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Pathology

Background:

  • Poncet's disease (PD) is a rare reactive arthritis associated with tuberculosis (TB).
  • Its pathogenesis remains unclear, and it is often a diagnosis of exclusion.
  • PD typically affects large joints and presents as oligo- or polyarthritis.

Observation:

  • A 16-year-old male presented with a two-month history of bilateral, symmetrical inflammatory polyarthralgia.
  • Associated symptoms included peripheral lymphadenopathy and hepatosplenomegaly.
  • Initial investigations for other causes of arthritis were inconclusive.

Findings:

  • Lymph node biopsy revealed epithelioid granulomas with caseating necrosis, indicative of tuberculosis.
  • Erythrocyte sedimentation rate was 60 mm/h and C-reactive protein was 91 mg/L.
  • The patient showed significant clinical improvement with anti-tuberculosis treatment.

Implications:

  • Poncet's disease should be considered in the differential diagnosis of inflammatory arthralgia, particularly in TB-endemic regions.
  • This case highlights the importance of considering tuberculosis in patients with unexplained inflammatory arthritis.
  • Prompt diagnosis and treatment of the underlying TB are essential for effective management of Poncet's disease.