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A Bioelectrochemical Crossbar Architecture Screening Platform (BiCASP) for Extracellular Electron Transfer.

Hasika Suresh1,2, Presley Bird3, Kundan Saha1,4

  • 1Sonkusale Research Labs, Tufts University, 171 College Avenue, Medford, MA 02155, USA.

Biorxiv : the Preprint Server for Biology
|July 17, 2025
PubMed
Summary

We developed a high-throughput platform, the Bioelectrochemical Crossbar Architecture Screening Platform (BiCASP), to accelerate the engineering of electroactive microbes for biotechnology. This innovation significantly speeds up data acquisition for bioelectrochemical systems (BES).

Keywords:
Arrayed microwellsShewanellabioelectrochemical systemsbioelectronicscrossbar architecturedecaheme proteinelectrical multiplexelectroactive microbeextracellular electron transferhigh-throughput screening

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Area of Science:

  • Biotechnology
  • Bioelectronics
  • Microbial Engineering

Background:

  • Electroactive microbes offer unique capabilities for biotechnology and electrical devices.
  • Current methods for characterizing these microbes in bioelectrochemical systems (BES) are low-throughput, hindering engineering efforts.

Purpose of the Study:

  • To develop a high-throughput platform for characterizing electroactive microbes.
  • To overcome the limitations of conventional BES for rapid screening of microbial components.

Main Methods:

  • Development of the Bioelectrochemical Crossbar Architecture Screening Platform (BiCASP).
  • Arraying and characterizing samples in individually addressable microwells.
  • Real-time current reporting from electroactive bacteria on a minute time scale.

Main Results:

  • BiCASP decreases data acquisition time by orders of magnitude compared to traditional BES.
  • The platform enables high-throughput screening of engineered biological components.
  • Identified mutants of the MtrA protein in *Shewanella oneidensis* that support extracellular electron transfer (EET).

Conclusions:

  • BiCASP significantly enhances the throughput for screening electroactive microbes.
  • This platform is expected to accelerate the design of new bioelectronic components.
  • Facilitates directed evolution of electroactive proteins for improved bioelectronic applications.