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[Apical hypertrophy and its genetic and acquired factors]
Journal of Cardiography. Supplement
|January 1, 1985
Summary
Apical hypertrophy, a form of hypertrophic cardiomyopathy (HCM), appears distinct from asymmetric septal hypertrophy (ASH) with a different inheritance pattern and a potential link to hypertension. This suggests it may be a separate disease entity within the HCM spectrum.
Area of Science:
- Cardiology
- Genetics
- Internal Medicine
Context:
- Apical hypertrophy (AH) is a variant of hypertrophic cardiomyopathy (HCM) with distinct electrocardiographic and echocardiographic features.
- The precise nosological position of AH within the HCM spectrum remains debated, necessitating comparative studies.
Purpose:
- To compare the demography, familial occurrence, and acquired factors of patients with AH versus those with asymmetric septal hypertrophy (ASH).
- To investigate the potential association of hypertension and abnormal blood pressure response during exercise with AH.
Summary:
- Apical hypertrophy predominantly affects middle-aged males and shows a lower familial occurrence compared to ASH, suggesting a different inheritance pattern.
- A significant association between apical hypertrophy and hypertension was observed, including abnormal blood pressure responses during exercise stress tests, even in normotensive individuals.
- These findings indicate that apical hypertrophy may represent a distinct disease entity within the hypertrophic cardiomyopathy spectrum.
Impact:
- Differentiates apical hypertrophy from ASH, aiding in more precise diagnosis and understanding of hypertrophic cardiomyopathy.
- Highlights the potential role of acquired factors like hypertension in the pathogenesis of apical hypertrophy.
- Provides evidence for distinct genetic and etiological pathways in different forms of hypertrophic cardiomyopathy.