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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
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Multimodal Wearable Platform with Simultaneous Electrochemical and Biophotonic Sensing.
Brendan Evert1, Kaila L Peterson1, Tanner Songkakul1
1Department of Electrical & Computer Engineering, North Carolina State University, 890 Oval Dr., Raleigh, North Carolina 27695, United States.
ACS Sensors
|July 17, 2025
Summary
This study introduces a novel wearable device integrating multiple sensors to monitor sweat biomarkers and cardiovascular activity. This innovation offers personalized health insights by correlating physiological dynamics during exercise.
Area of Science:
- Biomedical Engineering
- Wearable Technology
- Physiological Monitoring
Background:
- Multimodal wearables are emerging for personalized care, offering insights into physiological dynamics like sweat biomarkers and cardiovascular activity.
- Existing wearables often lack integrated sensing capabilities beyond a single modality (e.g., motion, biopotentials).
- Understanding the interplay between biochemical and physical signals during exertion is crucial for enhanced health monitoring.
Purpose of the Study:
- To develop and characterize a modular wearable platform integrating electrochemical, biophotonic, temperature, and motion sensing.
- To assess the system's performance in monitoring sweat lactate and pH, alongside other physiological parameters.
- To demonstrate the system's capability in observing correlations between physiological markers during exercise.
Main Methods:
- Designed a compact, low-power modular electrochemical platform with integrated sensors.
- Characterized system performance for sweat lactate and pH monitoring, local tissue oxygenation, heart rate, motion, and temperature.
- Conducted a proof-of-concept human study with six subjects during a high-intensity exercise protocol.
Main Results:
- The wearable system demonstrated sensitivities of -0.34 μA/mM for sweat lactate and -72 mV/pH for pH.
- Simultaneous monitoring of sweat lactate, pH, tissue oxygenation, heart rate, motion, and temperature was achieved.
- Observed a correlation between sweat lactate levels and local tissue oxygenation during intense physical activity.
Conclusions:
- The developed multimodal wearable platform offers a low-power, compact solution for integrated physiological monitoring.
- The system successfully monitored key biochemical and physical markers, demonstrating its potential for personalized health insights.
- This technology enables the study of interrelationships between physiological dynamics, particularly during physical exertion.
