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Updated: Sep 15, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
Selective Reductions of Esters to Aldehydes: Extended Scope and Downstream Reactivity
Rebeka Ločmele1,2, Gábor Szilvágyi3, József Répási3
1Laboratory of CNS Active Compounds, Latvian Institute of Organic Synthesis, Aizkraukles 21, 1006 Riga, Latvia.
None:
In our study, we extended the applicability of ester hydrosilylation methodology employing (2-bromo-6-fluorophenyl)bis(2,3,5,6-tetrafluorophenyl)borane (SBR12) catalysts. Overall, the method features exceptionally low catalyst loading (as little as 0.01 mol %), along with mild reaction conditions and a high tolerance for various functional groups. We demonstrated the practicality of this technique through the concise total synthesis of the sex pheromone (Z,Z)-7,11-hexadecadienal and the antipsychotic medication haloperidol.
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