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Hepatotoxicity induced by MK-677.

Era Cobani1, Md Shahnoor Amin2, Muneer Hasso2

  • 1Wayne State University School of Medicine, Detroit, Michigan, USA gh5767@wayne.edu.

BMJ Case Reports
|July 17, 2025
PubMed
Summary
This summary is machine-generated.

Growth hormone secretagogue MK-677 (Ibutamoren) is popular in supplements. This case study highlights a rare instance of liver injury (transaminitis) in a healthy male after two months of MK-677 use.

Keywords:
General practice / family medicineLiver diseaseNutritionVitamins and supplements

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Area of Science:

  • Endocrinology
  • Hepatology
  • Pharmacology

Background:

  • MK-677 (Ibutamoren) is a popular oral growth hormone secretagogue.
  • It is widely used as a performance-enhancing supplement.
  • Reported side effects include edema, increased appetite, and muscle pain, with hepatotoxicity being rare.

Purpose of the Study:

  • To report a case of drug-induced liver injury (DILI) associated with MK-677.
  • To highlight the potential for hepatotoxicity from MK-677 despite its rarity.

Main Methods:

  • Case report presentation.
  • Review of clinical presentation and laboratory findings.
  • Monitoring of liver function tests after supplement cessation.

Main Results:

  • A healthy male in his early 30s developed elevated liver enzymes (transaminitis).
  • The transaminitis occurred after two months of MK-677 consumption.
  • Liver function normalized after discontinuing the supplement.

Conclusions:

  • MK-677, despite its common use, may be associated with rare cases of hepatotoxicity.
  • Clinicians should consider MK-677 as a potential cause of liver injury in individuals using performance-enhancing supplements.
  • Further research is warranted to fully elucidate the hepatotoxic potential of MK-677.