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Updated: Sep 15, 2025

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Common bile duct dilatation on MRI in autosomal dominant polycystic kidney disease

Usama Sattar1, Chenglin Zhu1, Xiaorui Yin1

  • 1Weill Cornell Medicine, New York, USA.

Abdominal Radiology (New York)
|July 17, 2025
PubMed
Abstract

Insights

Autosomal dominant polycystic kidney disease (ADPKD) is linked to larger common bile duct (CBD) diameters. This finding in ADPKD patients may help reduce unnecessary diagnostic tests for non-obstructive CBD dilatation.

Area of Science:

  • Hepatology
  • Radiology
  • Genetics

Background:

  • Polycystic liver disease is a common manifestation of autosomal dominant polycystic kidney disease (ADPKD).
  • Common bile duct (CBD) dilatation has been anecdotally observed in ADPKD but not systematically studied due to limitations of CT scans for biliary visualization.

Purpose of the Study:

  • To measure CBD diameter using T2-weighted MRI in ADPKD subjects.
  • To determine if CBD dilatation is associated with ADPKD.

Main Methods:

  • Retrospective measurement of CBD diameter on T2-weighted MRI scans.
  • Comparison of CBD diameter between 254 ADPKD subjects and 254 age- and sex-matched controls.
  • Correlation of CBD diameter with clinical, laboratory, and MRI features, including organ volumes and cyst burden.

Main Results:

  • ADPKD subjects exhibited a 22% larger median CBD diameter (5.6 mm) compared to controls (4.6 mm) (p < 0.001).
  • A significantly higher proportion of ADPKD subjects (5.1%) had CBD diameter ≥ 10 mm versus controls (0.4%) (p < 0.001).
  • Multivariable analysis indicated PKD1/PKD2 mutation presence and age were associated with increased CBD diameter, while serum albumin was associated with decreased diameter.

Conclusions:

  • ADPKD is associated with significantly larger CBD diameters and a higher likelihood of non-obstructive CBD dilatation (≥ 10 mm).
  • Awareness of this association may help clinicians avoid unnecessary diagnostic procedures in ADPKD patients.
  • T2-weighted MRI is an effective tool for assessing CBD diameter in ADPKD.
Keywords:
AlbuminBiliaryDilatationObstructionPKD1PKD2

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