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Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

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Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
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Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

203
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
203
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

331
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
331
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

626
Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
626
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

541
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
541

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Updated: Sep 15, 2025

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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Movement disorders associated with diarrhoea.

Claudia Lazcano-Ocampo1,2, Tobias Warnecke3, Iro Boura4

  • 1Department of Neurology, Institute of Diagnosis INDISA, 1810 Santa Maria Avenue, Santiago, Chile. c.lazcano.ocampo@gmail.com.

Journal of Neural Transmission (Vienna, Austria : 1996)
|July 17, 2025
PubMed
Summary
This summary is machine-generated.

Diarrhoea, often overlooked, is linked to movement disorders. This review highlights intestinal hypermotility

Keywords:
AtaxiaDiarrhoeaGastrointestinal hypermotilityMovement disordersParkinsonismTremor

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Area of Science:

  • Neurogastroenterology
  • Movement Disorders
  • Neurology

Background:

  • The gut-brain axis is crucial in neurodegenerative and movement disorders.
  • Gastrointestinal hypomotility (constipation) is well-studied.
  • Intestinal hypermotility (diarrhoea) is an under-recognized clinical and research gap.

Purpose of the Study:

  • To review movement disorders associated with diarrhoea.
  • To provide a clinical overview of diarrhoea as a gastrointestinal manifestation.
  • To address the research gap concerning hypermotility and neurological dysfunction.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of acquired (infectious, toxic, metabolic, autoimmune) and inherited causes.
  • Examination of diarrhoea characteristics and underlying pathophysiological mechanisms.

Main Results:

  • Diarrhoea can precede movement disorder onset.
  • Diarrhoea is prominent in hyperkinetic disorders (ataxia, myoclonus, tremor).
  • In hypokinetic disorders, diarrhoea is often drug-associated or overflow.

Conclusions:

  • Diarrhoea is a significant gastrointestinal symptom in various movement disorders.
  • Understanding the link between bowel hypermotility and neurological dysfunction is essential.
  • Further research is needed to explore this bidirectional relationship.