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Cardiac Manifestations in Behçet's Syndrome

Federica Bello1, Giacomo Bagni1,2, Emire Seyahi3

  • 1Department of Experimental and Clinical Medicine, University of Florence, Italy and Internal Interdisciplinary Unit, Behçet Centre, Careggi University Hospital, Florence, Italy.

Current Rheumatology Reports
|July 17, 2025
PubMed

Insights

Behçet's Syndrome (BS) can impact the heart, causing various cardiac issues. Early diagnosis and treatment, including biologics, are vital for managing BS cardiovascular complications and improving patient outcomes.

Area of Science:

  • Cardiology
  • Rheumatology
  • Immunology

Background:

  • Behçet's Syndrome (BS) is a multisystemic vasculitis with potential cardiac manifestations.
  • Cardiac involvement in BS can include pericarditis, myocarditis, thrombosis, and coronary artery disease.

Purpose of the Study:

  • To review the clinical presentation of cardiac involvement in Behçet's Syndrome.
  • To discuss diagnostic challenges associated with cardiac BS.
  • To summarize therapeutic strategies for managing cardiac complications in BS.

Main Methods:

  • Literature review of clinical presentations, diagnostic methods, and treatment outcomes.
  • Analysis of advanced imaging findings in cardiac BS.
  • Evaluation of current and emerging therapeutic options.

Main Results:

  • Advanced imaging reveals subclinical cardiac involvement in BS.
  • Myocardial dysfunction, fibrosis, and intracardiac thrombi are significant findings.
  • Coronary artery vasculitis in BS can mimic atherosclerotic disease.
  • Biologic therapies, such as TNF-α inhibitors, show efficacy in refractory cases.

Conclusions:

  • Early diagnosis and immunosuppressive therapy are critical for managing cardiac BS.
  • A multidisciplinary approach is essential for optimal patient outcomes.
  • Further research is needed for refined screening and targeted immunotherapies.
Abstract

Keywords:
AneurysmsBehçetMyocarditisPericarditisThrombosisVasculitis

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