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Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

793
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
793

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Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
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Progress in recapitulating morphogenesis of blood microvascular structures for microphysiological systems

Ana Ximena Monroy-Romero1,2, Mathieu Hautefeuille2

  • 1Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Biochemical Society Transactions
|July 18, 2025
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Summary

Microphysiological systems (MPSs) use self-organization to create vascular networks, mimicking in vivo processes like vasculogenesis and angiogenesis. This approach enhances MPS for drug development and disease modeling.

Keywords:
microfluidicsmicrophysiological systemsmicrovesselsmorphogenesisorgan-on-chipvasculature

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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Tissue Engineering

Background:

  • Microphysiological systems (MPSs) aim to replicate human tissue microenvironments for research.
  • Vascular networks are crucial in MPS for nutrient transport and cell viability.
  • Traditional top-down engineering of vascular networks in MPS is less effective than bottom-up self-organization.

Purpose of the Study:

  • To review the mechanisms of vascular self-organization in vitro.
  • To highlight the integration of these mechanisms into tissue-specific MPS platforms.
  • To emphasize the role of vascularization in advancing MPS applications.

Main Methods:

  • Review of in vivo vascularization processes (vasculogenesis and angiogenesis).
  • Analysis of microenvironmental cues driving self-organization (cell factors, ECM, flow).
  • Exploration of bottom-up approaches for recapitulating microvasculature geometry in MPS.

Main Results:

  • Self-organization paradigms are more effective for mimicking microvasculature networks and capillary diameters.
  • In vivo vascular formation relies on coordinated steps driven by specific microenvironmental cues.
  • Incorporating these cues into MPS platforms enables physiologically relevant vascularization.

Conclusions:

  • Vascular self-organization is key to developing advanced, vascularized MPS.
  • Physiologically relevant MPS enhance capabilities for drug development and disease modeling.
  • Understanding and applying self-organization principles will improve MPS functionality.