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Updated: Sep 15, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
Comparing Combined Lidocaine Transdermal Patch and Lidocaine Subcutaneous Injection Versus Lidocaine Subcutaneous
Arata Hagikura1, Kazuki Moriwaki, Hayato Tanaka
1Tsukazaki Hospital, Osaka Metropolitan University, Osaka, Japan.
Objectives:
The optimal local anesthetic for trans-distal radial (TDRA) and trans-radial arterial (TRA) catheterization is unclear and not standardized. This study compared the efficacy and cost-effectiveness of adding a lidocaine patch to standard lidocaine subcutaneous lidocaine injection for TDRA and TRA procedures.
Methods:
This was a prospective, single-blind study. Consecutive patients undergoing TDRA or TRA catheterization in patients with ischemic heart and peripheral arterial disease were randomized to receive either a lidocaine patch (lidocaine group, n=41) or a placebo patch (placebo group, n=43) at the planned arterial access site at least 30 minutes before the procedure, followed by lidocaine subcutaneous anesthesia using a 27-G needle. The primary outcome was access site pain measured by visual analog scale (VAS) at predetermined 3 points (1) at the point of lidocaine subcutaneous injection (referred to as "before procedure" hereafter), (2) during the procedure ("during procedure"), (3) postprocedure until the confirmation of arterial hemostasis ("after procedure"). Secondary outcomes included drug-related costs.
Results:
VAS scores at all 3 points were comparable (lidocaine vs. placebo: at the point of lidocaine infusion 20 mm vs. 19 mm, P =0.55; during the procedure 17 mm vs. 14 mm, P =0.67; after the procedure 9 mm vs. 12 mm, P =0.71). The lidocaine group incurred significantly higher costs, even when considering only the lidocaine patch (0.43 USD vs. 0.00 USD, P <0.001) and the total amount of lidocaine patch and lidocaine subcutaneous infusion (0.62 USD vs. 0.21 USD, P <0.001).
Discussion:
The addition of a lidocaine patch to standard lidocaine subcutaneous injection for TDRA or TRA catheterization did not improve pain relief or cost-effectiveness.
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