The Refractive Parameters of Treated Retinoblastoma Eyes

The study aimed to investigate the effect of treated retinoblastoma on refractive parameters.

A case-control study was conducted in the ophthalmology department at Ain Shams University from September 2023 to April 2024. Refractive parameters of treated retinoblastoma eyes were compared to those of age matched: (a) fellow eyes of unilateral retinoblastoma children, (b) normal eyes of healthy controls. Cycloplegic refraction, ocular biometry, and anterior segment optical coherence tomography were performed. Image J software was used to calibrate the radii of curvature of lens surfaces.

The study included 35 diseased eyes and 25 fellow eyes of 49 retinoblastoma subjects as well as 26 normal eyes of 26 healthy controls. A statistically significant difference existed between retinoblastoma eyes and eyes of healthy controls regarding refractive astigmatism (p = 0.02), corneal astigmatism (p = 0.047), anterior chamber depth (p < 0.001), and posterior lens curvature (p = 0.041). A statistically significant difference existed between RB eyes and fellow eyes regarding refractive astigmatism (p < 0.001) and corneal astigmatism (p = 0.001). There was no statistically significant difference between fellow eyes and eyes of healthy controls regarding any of refractive parameters.

Treated retinoblastoma eyes had shallower anterior chamber, more rounded lens, more astigmatic corneas, and more refractive astigmatism than healthy eyes.