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Multifocal visual evoked potential for evaluation of open-angle glaucoma.

Mostafa EmadEldeen Hussien Mohamed Afify1, Randa Hesham Ali Abdelgawad1, Momen Mahmoud Hamdi1

  • 1Ophthalmology Department, Ain Shams University Hospitals, Cairo, Egypt.

Medical Hypothesis, Discovery & Innovation Ophthalmology Journal
|August 29, 2023
PubMed
Summary
This summary is machine-generated.

Multifocal visual evoked potential (mfVEP) shows promise for assessing primary open-angle glaucoma (POAG). This objective tool correlates well with visual field and optical coherence tomography (OCT) measurements in POAG patients.

Keywords:
POAGSD-OCTbest-corrected visual acuitylogarithm of the minimum angle of resolutionmfVEPmultifocal visual evoked potentialprimary open-angle glaucomaretinal nerve fiber layer thicknessspectral-domain optical coherence tomographystatic automated perimetryvisual field

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Accurate assessment of visual field (VF) and retinal nerve fiber layer (RNFL) thickness is crucial for POAG management.
  • Objective electrophysiological tools are needed to complement existing diagnostic methods.

Purpose of the Study:

  • To correlate multifocal visual evoked potential (mfVEP) findings with static automated perimetry (SAP) and spectral-domain optical coherence tomography (SD-OCT) in eyes with POAG.
  • To evaluate the potential of mfVEP as an objective measure of visual function in POAG.

Main Methods:

  • Cross-sectional study of 40 eyes from 40 POAG patients.
  • Comprehensive ophthalmologic assessment including axial length measurement.
  • Evaluations using SAP, SD-OCT, and mfVEP.

Main Results:

  • mfVEP upper-ring signal-to-noise ratio (SNR) correlated negatively with visual acuity and positively with superior VF and inferior RNFL thickness.
  • mfVEP lower-ring SNR correlated negatively with visual acuity and positively with inferior VF and superior RNFL thickness.
  • These correlations suggest mfVEP reflects glaucomatous damage in POAG.

Conclusions:

  • mfVEP is a promising objective tool for assessing the visual field in POAG patients.
  • mfVEP findings positively correlate with VF and OCT RNFL thickness.
  • Further longitudinal studies with larger sample sizes are warranted to confirm these preliminary findings.