Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple-hole approach to zero-order release.

W Y Kuu, S H Yalkowsky

    Journal of Pharmaceutical Sciences
    |September 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study presents a novel device for near zero-order drug delivery. By optimizing hole density and configuration in an impermeable membrane, consistent drug release is achieved.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A 'rule of unity' for human intestinal absorption.

    Pharmaceutical research·2006
    Same author

    Solubilization of cyclosporin A.

    AAPS PharmSciTech·2004
    Same author

    A simple modified absorption potential.

    Pharmaceutical research·2002
    Same author

    Comparison of two methods for predicting aqueous solubility.

    Journal of chemical information and computer sciences·2001
    Same author

    Prediction of aqueous solubility of organic compounds by the general solubility equation (GSE).

    Journal of chemical information and computer sciences·2001
    Same author

    Use of pure t-butanol as a solvent for freeze-drying: a case study.

    International journal of pharmaceutics·2001

    Area of Science:

    • Materials Science
    • Pharmaceutical Sciences
    • Biomedical Engineering

    Background:

    • Achieving consistent drug release profiles is crucial for effective therapeutic outcomes.
    • Traditional drug delivery systems often struggle with variable release rates, leading to suboptimal dosing.
    • Zero-order drug delivery aims to provide a constant release rate over time.

    Purpose of the Study:

    • To introduce a new device design for achieving near zero-order drug release.
    • To demonstrate the feasibility of controlling drug release kinetics through membrane engineering.

    Main Methods:

    • Development of a drug delivery device featuring a uniformly perforated impermeable membrane.
    • Loading the device interior with a drug suspension within a polymeric matrix.

    Related Experiment Videos

  • Investigating the effect of hole density and surface configuration on drug release.

    • Main Results:

    • The developed device demonstrated near zero-order drug release kinetics.
    • The release rate was significantly influenced by the density and arrangement of holes on the membrane surface.
    • The polymeric matrix effectively contained the drug suspension.

    Conclusions:

    • The proposed device design offers a promising approach for controlled, near zero-order drug delivery.
    • Membrane perforation engineering is a viable strategy to modulate drug release profiles.
    • This technology has potential applications in pharmaceutical formulations requiring sustained and predictable drug administration.