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Ovarian Function Restoration Using Autologous Platelet-Rich Plasma.

Zijia Guo1, Kazuhiro Kawamura2

  • 1Department of Obstetrics and Gynecology Juntendo University Graduate School of Medicine Tokyo Japan.

Reproductive Medicine and Biology
|July 18, 2025
PubMed
Summary

Platelet-rich plasma (PRP) shows potential for improving ovarian function in women with diminished ovarian reserve. Further research is needed to clarify its mechanisms and optimize treatment protocols for better reproductive outcomes.

Keywords:
oocyte qualityovarian functionplatelet‐rich plasmaprimordial folliclesreproductive medicine

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Area of Science:

  • Reproductive Medicine
  • Regenerative Therapy

Background:

  • Increasing incidence of diminished ovarian reserve (DOR) and premature ovarian insufficiency (POI) due to delayed childbearing.
  • Limited effective treatments for ovarian function restoration.
  • Platelet-rich plasma (PRP) as a potential autologous regenerative therapy for ovarian function.

Purpose of the Study:

  • To review current preclinical and clinical evidence on the effects of PRP on ovarian function.
  • To understand the mechanisms of action and identify optimal treatment protocols for PRP in ovarian restoration.

Main Methods:

  • Literature review of studies published from January 2021 to March 2025.
  • Searches conducted on PubMed and Google Scholar.
  • Focus on preclinical and clinical studies evaluating PRP's impact on ovarian function.

Main Results:

  • Preclinical evidence suggests PRP promotes primordial follicle activation and enhances oocyte quality via angiogenesis, anti-inflammatory, and antioxidative effects.
  • Clinical studies indicate PRP may increase retrieved oocytes and improve some ovarian reserve markers.
  • Impact on oocyte quality and pregnancy rates remains inconclusive; optimal dosage and duration require further study.

Conclusions:

  • PRP demonstrates promise in reproductive medicine for ovarian function restoration.
  • Further research is essential to evaluate long-term effects and optimize treatment protocols.
  • Standardization of PRP preparation methods is necessary for consistent clinical application.