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Fibrosing Mediastinitis in a 5-Year-Old Labrador Retriever
Kyle L Granger1, Julien Guillaumin1, Kurt Williams2
1Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Veterinary Medicine and Science
|July 18, 2025
Summary
This is the first reported case of fibrosing mediastinitis (FM) in a dog. The condition caused severe respiratory distress and was confirmed post-mortem in a Labrador Retriever.
Area of Science:
- Veterinary Pathology
- Comparative Medicine
- Rare Diseases
Background:
- Fibrosing mediastinitis (FM) is a rare condition of excessive fibrous tissue in the mediastinum.
- In humans, FM can cause severe respiratory and hemodynamic compromise.
- FM has not been previously documented in canine species.
Observation:
- A 5-year-old Labrador Retriever presented with progressive respiratory distress, facial swelling, and pleural effusion.
- Imaging revealed a mediastinal mass, enlarged lymph nodes, bronchial and vascular narrowing, and organ compression.
- The dog showed poor response to treatment and was euthanized.
Findings:
- Post-mortem examination confirmed severe chronic mediastinal inflammation with fibrosis and vasculitis.
- Histopathology was consistent with fibrosing mediastinitis.
- This represents the first documented case of FM in a dog.
Implications:
- This case expands the known species affected by fibrosing mediastinitis.
- Highlights the importance of considering FM in canine cases with similar clinical signs.
- May prompt further investigation into the causes and potential treatments of FM in dogs.
