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The Reduction of COMP Serves as a Predictor for Warning of Aortic Dissection Progression

Zhuofan Li1, Ze Gong2, Weihao Li3

  • 1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.

JACC. Basic to Translational Science
|July 18, 2025
PubMed

Insights

Reduced cartilage oligomeric matrix protein (COMP) in plasma may indicate thoracic aortic dissection (TAD) progression. COMP appears to protect against TAD development and vascular damage, suggesting its potential as a novel biomarker.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Vascular Biology

Background:

  • Thoracic aortic dissection (TAD) is a critical cardiovascular condition with high mortality rates.
  • Current diagnostic and monitoring methods for TAD lack novel biomarkers.
  • Identifying new biomarkers is crucial for improving TAD patient outcomes.

Purpose of the Study:

  • To investigate cartilage oligomeric matrix protein (COMP) as a potential biomarker for thoracic aortic dissection (TAD).
  • To evaluate the role of COMP in the pathogenesis and progression of TAD.
  • To explore COMP's therapeutic potential in preventing or mitigating TAD.

Main Methods:

  • A case-control study involving 362 TAD patients and 136 controls was conducted.
  • Plasma COMP levels were measured and analyzed to identify significant differences.
  • The protective function of COMP was further examined using two distinct mouse models of TAD.

Main Results:

  • A significant and sustained decrease in plasma COMP levels was observed in TAD patients compared to controls.
  • Experimental models demonstrated that COMP can suppress TAD development.
  • COMP was found to ameliorate vascular pathogenesis associated with TAD.

Conclusions:

  • Decreased plasma COMP levels may serve as a novel and valuable biomarker for monitoring TAD progression.
  • COMP exhibits a protective role against the development of TAD.
  • COMP has the potential to be a therapeutic target for mitigating vascular damage in TAD.

Keywords:
Marfan syndromebiomarkercartilage oligomeric matrix proteinthoracic aortic dissectionβ-aminopropionitrile

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