Fat, fib, and forgetfulness: The interplay between adiposity, atrial fibrillation, and dementia

Atrial Fibrillation, dementia, and obesity are prevalent and interconnected pathologic states with significant morbidity and mortality and increasing global incidence. This review examines the current literature regarding the known and hypothesized relationships between these three conditions, their risk factors, and treatment strategies. We aim to highlight a stepwise and potentially causative interplay between them. As all three states become increasingly common in clinical practice, a detailed understanding of their multifactorial and multimodal relationship becomes critical for effective multidisciplinary care. Appropriate treatment of each is likely to reduce the burden of all three.