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Updated: Sep 14, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
New Insights into the Pathogenesis of Psoriatic Arthritis
Maria de la Luz Garcia-Hernandez1, Christopher T Ritchlin1, Diamond R Guy2
1Allergy, Immunology & Rheumatology Division, University of Rochester Medical Center, 575 Elmwood Avenue, Rochester, NY 14620, USA.
Abstract:
In the current paradigm, psoriatic arthritis (PsA) pathogenesis is generated and sustained by combined innate and immune disease mechanisms dominated by the IL-23/IL-17 axis. The current challenge is to define tissue-specific endotypes and associated biomarkers with the goal to develop a precision medicine-based approach. In this article, we discuss the current pathogenetic landscape in PsA and outline the path forward to define tissue-specific endotypes. A more complete understanding of the cellular and molecular heterogeneity in specific target tissues and the development of models that recapitulate human disease will accelerate the rationale development of tissue domain-guided personalized therapies in PsA.
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