Related Experiment Video
Updated: Sep 14, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
Novel Therapeutic Targets in the Management of Psoriatic Disease
Beth A Childs1, Joseph F Merola1
1Departments of Dermatology and Medicine, Division of Rheumatology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9069, USA.
Abstract:
The treatment landscape for psoriatic disease is rapidly evolving, offering improved disease control and enhanced quality of life. This article highlights an expanding repertoire of therapies, including biologics targeting key cytokines, nanobody-based treatments for greater stability and cost-efficiency, and long-acting antibodies to reduce dosing frequency. Combination approaches improve outcomes in refractory cases, while glucagon-like peptide 1 receptor agonists address systemic inflammation and comorbidities. Cell-targeted therapies provide precision and fewer side effects by focusing on pathogenic cells. Paired with advancements in predictive medicine, these innovations signify a shift toward safer, more personalized therapies that redefine psoriatic disease management.
Related Concept Videos
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Targets for Drug Action: Overview
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Targeted Cancer Therapies
There are several types of targeted therapies against...
Atherosclerosis III: Management

