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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Updated: Sep 14, 2025

Routine Screening Method for Microparticles in Platelet Transfusions
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Platelets: tailoring metastasis treatment.

Vincent Mittelheisser1, Cristina Liboni1, Silvia Maria Grazia Trivigno2

  • 1Tumor Biomechanics lab, Strasbourg, France; INSERM UMR_S1109, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France; Equipe Labellisée Ligue Contre le Cancer, Strasbourg, France.

Trends in Cancer
|July 18, 2025
PubMed
Summary
This summary is machine-generated.

Platelets significantly aid cancer metastasis by supporting tumor cell survival and spread. New research highlights novel platelet roles beyond the bloodstream, identifying potential therapeutic targets for cancer treatment.

Keywords:
metastasisplateletstherapytumor

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Area of Science:

  • Oncology
  • Hematology
  • Cancer Metastasis Research

Background:

  • Platelets have long been known to interact with tumor cells.
  • Extensive research details platelet roles in primary tumor growth, circulating tumor cell survival, and metastasis.
  • Current understanding of platelet involvement in cancer progression necessitates further investigation for therapeutic development.

Purpose of the Study:

  • To summarize recent findings on novel platelet functions in metastasis.
  • To explore platelet contributions to cancer spread beyond the vasculature.
  • To identify potential platelet-derived molecular targets for anti-metastasis therapies.

Main Methods:

  • Literature review of recent discoveries in platelet-cancer interactions.
  • Analysis of studies focusing on extravascular roles of platelets in metastasis.
  • Identification and discussion of platelet-borne molecular targets.

Main Results:

  • Platelets influence cancer metastasis through mechanisms extending beyond their intravascular functions.
  • Emerging evidence reveals new pathways by which platelets promote tumor cell dissemination and outgrowth.
  • Specific platelet-derived molecules are implicated as potential therapeutic targets.

Conclusions:

  • Platelets play multifaceted roles in cancer metastasis, including extravascular functions.
  • Targeting platelet-mediated metastasis offers promising therapeutic avenues.
  • Further research into platelet-borne targets could lead to novel anti-cancer strategies.