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Updated: Sep 14, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
A comprehensive explainable AI approach for enhancing transparency and interpretability in stroke prediction
Marwa El-Geneedy1,2, Hossam El-Din Moustafa3, Hatem Khater4
1Electronics and Communications Engineering Department, Faculty of Engineering, Mansoura University, Mansoura, 35516, Egypt. melgeneedy@std.mans.edu.eg.
Abstract:
Stroke is among the leading causes of death, especially among old adults. Thus, the mortality rate and severe cerebral disability can be avoided when stroke is diagnosed at its early stages, followed by subsequent treatment. There is no doubt that healthcare specialists can find the necessary solutions more effectively and instantly with the help of artificial intelligence (AI) and machine learning (ML). In this study, we used ML classifiers and explainable artificial intelligence (XAI) to predict stroke. Six different ML classifiers that trained on available datasets for stroke patients. Six feature selection methodologies were used to extract essential features from the dataset. The XAI methods applied (Shapley Additive Values (SHAP), ELI5, and Local Interpretable Model-agnostic Explanations (LIME)). This study provides preliminary insights that may support the development of future tools to assist medical practitioners in managing patients, pending further clinical validation and real-world testing.
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