Related Experiment Video

Updated: Sep 14, 2025

Author Spotlight: Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures
04:01

Author Spotlight: Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures

Published on: June 23, 2023

1.9K

Cas12a mice enable the rapid generation of highly complex tumour genotypes

Jess D Hebert1

  • 1Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. jdhebert@stanford.edu.

Nature Reviews. Cancer
|July 18, 2025
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

9.6K
Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein
05:48

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

Published on: March 16, 2022

2.7K

Related Experiment Videos

Last Updated: Sep 14, 2025

Author Spotlight: Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures
04:01

Author Spotlight: Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures

Published on: June 23, 2023

1.9K
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

9.6K
Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein
05:48

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

Published on: March 16, 2022

2.7K

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.7K

Articles linked to this work by shared authors, journal, and citation graph.

Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression.

Nature aging·2025

Functional Mapping of Epigenomic Regulators Uncovers Coordinated Tumor Suppression by the HBO1 and MLL1 Complexes.

Cancer discovery·2025

Efficient and multiplexed somatic genome editing with Cas12a mice.

Nature biomedical engineering·2025

Combinatorial In Vivo Genome Editing Identifies Widespread Epistasis and an Accessible Fitness Landscape During Lung Tumorigenesis.

Molecular biology and evolution·2025

A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis.

The Journal of experimental medicine·2024

Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes.

bioRxiv : the preprint server for biology·2024

Brain barriers at the crossroads of glioma immune surveillance and immunotherapy response.

Nature reviews. Cancer·2026

The DNA damage response and cancer immunotherapy.

Nature reviews. Cancer·2026

Igniting antitumour immunity with cancer cell pyroptosis.

Nature reviews. Cancer·2026

A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia.

Nature reviews. Cancer·2026

Systemic health impact of cancer-associated extracellular vesicles and particles.

Nature reviews. Cancer·2026

Imaging the hallmarks of cancer.

Nature reviews. Cancer·2026

Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice.

Genetics·2026

Molecular clusters and precision medicine in pheochromocytomas and paragangliomas.

Endocrine-related cancer·2026

Short-term outcomes of a randomized, mixed-methods trial to improve hereditary cancer test results disclosure and follow-up communication with family.

Genetics in medicine : official journal of the American College of Medical Genetics·2026

Genetic associations and candidate functional genes linking depression and obesity: a multi-omics integrative study.

Frontiers in genetics·2026

Multi-Site Aggregation of p53: Insights from Self- and Co-Aggregation of Multiple Aggregation-Prone Regions.

ACS omega·2026

Sex differences in the pathogenesis of degenerative knee osteoarthritis: a comparative transcriptomics analysis.

Frontiers in aging·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us