Related Experiment Video
Updated: Jul 7, 2026

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
Published on: October 20, 2014
SENP1: A perspective from immune cells to disease (Review)
Xiaofang Feng1, Guoyu Wu2, Qiyan Zeng3
1Department of Nuclear Medicine, Minzu Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region 530001, P.R. China.
None:
Small ubiquitin‑like modifier (SUMO) is a ubiquitin‑like protein that modifies target proteins across various eukaryotic subcellular structures. This process, known as SUMOylation, has been established as an essential regulatory mechanism that affects both the activity and positioning of proteins, maintaining cellular homeostasis. SUMOylation and deSUMOylation are reversible post‑translational modification processes mediated by SUMO proteins and SUMO/sentrin‑specific proteases (SENPs). The human SENP family comprises six members, each characterized by unique cellular localization and substrate specificity. The present review primarily summarizes the role and mechanisms of SENP1 in the development and maturation of immune cells, including lymphocytes, macrophages and erythrocytes, as well as its involvement in tumor cell invasion, metastasis, angiogenesis and resistance to pharmacological therapies. In addition, the introduction of SENP1 inhibitors as a therapeutic approach for cancer treatment is explored. Overall, the present study aimed to offer theoretical insights into cancer therapy strategies that target SENP1.
More Related Videos
Related Concept Videos
Regulation of Hematopoietic Stem Cells
EPS and iPS Cells in Disease Research
Cells of the Innate Immune Response
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cells of the Adaptive Immune Response
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

