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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Mouse Models of Cancer Study02:43

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

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Biomechanical Testing of Murine Tendons
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A Novel 3D-Printed Mouse Model for Surgical Training: Multicenter Construct, Face, and Content Validation Study.

Diego Celdran-Bonafonte1, Felix Gantenbein2, Daniel Ruiz Perez3

  • 11University Animal Care, The University of Arizona, Tucson, Arizona.

Journal of the American Association for Laboratory Animal Science : JAALAS
|July 19, 2025
PubMed
Summary
This summary is machine-generated.

A new 3D-printed rodent surgical simulator effectively trains basic skills, aligning with the 3Rs (Replacement, Reduction, Refinement) of animal research. This technology offers a realistic and ethical alternative for surgical education.

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Area of Science:

  • Biomedical Engineering
  • Veterinary Surgery
  • Laboratory Animal Science

Background:

  • Laboratory animal training increasingly uses technology to align with the 3Rs (Replacement, Reduction, Refinement).
  • Traditional methods rely on live animals and cadavers, prompting a shift towards simulation-based training.
  • There is a need for effective, ethical alternatives in rodent surgical skills education.

Purpose of the Study:

  • To introduce and validate a novel 3D-printed rodent surgical simulator.
  • To assess the simulator's potential to replace, refine, and reduce animal use in training.
  • To evaluate the simulator's face, content, and construct validity for basic rodent surgical skills.

Main Methods:

  • A multicenter validation study was conducted across 5 European and US research academic centers.
  • Participants included those inexperienced and expert in rodent surgery.
  • Construct validity was assessed via task completion times and blinded quality assessments over multiple training iterations.

Main Results:

  • Inexperienced participants showed significant improvements in surgical task speed and quality with simulator use.
  • Repeated simulator use led to performance levels comparable to experts' initial attempts.
  • Expert participants consistently outperformed the inexperienced group, and high ratings supported face and content validity.

Conclusions:

  • The 3D-printed rodent surgical simulator is a realistic and effective tool for basic surgical skills training.
  • The simulator offers an ethically sound alternative, supporting the 3Rs principles in laboratory animal science.
  • This technology aids in competency assessment and reduces reliance on animal models for surgical education.