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Updated: Sep 14, 2025

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
Breaking tolerance: an update of Treg dysfunction in autoimmunity
Nardos T Cheru1, Yemi Osayame1, Tomokazu S Sumida1
1Yale School of Medicine, 300 George St, New Haven, CT 06511, USA.
Abstract:
FOXP3+ regulatory T cells (Tregs) are essential for maintaining immune tolerance, and their dysfunction is a hallmark of autoimmune diseases. Recent studies have identified key transcriptional, metabolic, and environmental drivers of Treg instability and loss of function. Understanding these mechanisms opens new avenues for therapeutic interventions aimed at restoring immune homeostasis in autoimmunity.
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