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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Structure characterization and construction analysis of a calcium-vitamin D3 co-delivery aqueous solution system
Yifu Zhang1, Jiawang Zhang2, Yuanda Zhao2
1College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China; College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
Abstract:
A aqueous co-delivery system for calcium ions (Ca2+) and vitamin D3 (VD3) was developed to achieve their co-loading and synergistic release. The quaternary complex α-cyclodextrin-VD3@casein phosphopeptide‑calcium chelate (α-CD-VD3@CPP-Ca2+), prepared from α-CD-VD3 and CPP-Ca2+, exhibited a particle size of 419.46 ± 1.52 nm and a zeta potential of -28.39 ± 1.21 mV. Spectroscopic analysis revealed that α-CD-VD3 and CPP-Ca2+ were associated via hydrogen bonds and van der Waals forces. The complex showed good dispersibility in aqueous solution and enhanced stability across different pH values and salt ion environments. In vitro release experiments indicated that the complex remained stable in simulated gastric fluid (SGF) and achieved high release efficiencies of 78.39 % for VD3 and 84.12 % for Ca2+ in simulated intestinal fluid (SIF). This study provides an effective solution for improving the synergistic utilization of VD3 and Ca2+.
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