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Updated: Sep 14, 2025

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
Published on: April 29, 2010
From cooperation to conflicts - A complicated relationship between transcription and replication
Syed Shahid Musvi1, Tatiana N Moiseeva2
1Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.
Abstract:
A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated initiation of DNA replication result in transcription replication conflicts and DNA damage. Interestingly, many replication origins are co-localized with transcription start sites, indicating that transcription may play a role in the initiation of DNA replication. In this review we cover various aspects of replication regulation by transcription - from location of replication origins to various steps of replication initiation, replication timing and transcription-replication conflicts.
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